Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2
نویسندگان
چکیده
منابع مشابه
Blockade of glioma proliferation through allosteric inhibition of JAK2.
The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal antibodies in glioblastomas that also have mutation or deletion of the gene encoding phosphatase and tensin homolog (PTEN) has been modest. We found that EGFR signaling wa...
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BACKGROUND Gliomas are the most common primary tumors in central nervous system. The prognosis of the patients with glioma is poor regardless of the development of therapeutic strategies. Its aggressive behavior mainly depends on the potent ability of proliferation. The transcription factor EGR1 (early growth response 1) is a member of a zinc finger transcription factor family which plays an es...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2013
ISSN: 1945-0877,1937-9145
DOI: 10.1126/scisignal.2003900